Impairment of the myocardial vasomotor response to cold pressor stress in collateral dependent myocardium

摘要

Conclusions-In contrast to the decrease in myocardial resistance in remote myocardium with cold pressor, an increase was observed in collateral depen- dent myocardium suggesting a vaso- constrictor response in resistive vessels, without demonstrable myocardial ischaemia. Objective-To study the vasomotor Response (cold pressor/basal flow) in Myocardium perfused entirely by collat- Erals, using the reflex sympathetic stimu- Lation of cold pressor stress. Design-Regional myocardial blood flow Was measured in collateral dependent and In remote myocardium using positron Emission tomography with ~15O water at Basal and at cold pressor stress. Regional Ischaemia was measured with ~18F-fluoro- Deoxyglucose (FDG).