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Writing biology with mutant mice: The monstrous potential of post genomic life

机译:用突变小鼠书写生物学:后基因组生活的巨大潜力

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摘要

Social scientific accounts identified in the biological grammars of early genomics a monstrous reduction-ism, 'an example of brute life, the minimalist essence of things' (Rabinow, 1996, p. 89). Concern about this reductionism focused particularly on its links to modernist notions of control; the possibility of calculating, predicting and intervening in the biological futures of individuals and populations. Yet the trajectories of the post genomic sciences have not unfolded in this way, challenging scientists involved in the production and integration of complex biological data and the interpretative strategies of social scientists honed in critiquing this reductionism. The post genomic sciences are now proliferating points from which to understand relations in biology, between genes and environments, as well as between species and spaces, opening up future possibilities and different ways of thinking about life. This paper explores the emerging topologies and temporalities of one form of post genomic research, drawing upon ethnographic research on international efforts in functional genomics, which are using mutant mice to understand mammalian gene function. Using vocabularies on the monstrous from Derrida and Haraway, I suggest an alternative conceptualisation of monstrosity within biology, in which the ascendancy of mice in functional genomics acts as a constant supplement to the reductionist grammars of genomics. Rather than searching for the minimalist essence of things, this form of functional genomics has become an exercise in the production and organisation of biological surplus and excess, which is experimental, corporeal and affective. The uncertain functioning of monsters in this contexts acts as a generative catalyst for scientists and social scientists, proliferating perspectives from which to listen to and engage with the mutating landscapes, forms of life, and languages of a post genomic biology.
机译:社会科学文献在早期基因组学的生物学语法中确定了一种巨大的还原主义,“简朴的生活的例子,事物的最低限度的本质”(Rabinow,1996,第89页)。对这种简化主义的关注尤其集中在它与现代主义控制观念的联系上。计算,预测和干预个人和人群生物未来的可能性。然而,后基因组科学的轨迹并没有以这种方式展现出来,挑战着参与复杂生物学数据的产生和整合的科学家,以及挑战这种还原论的社会科学家的解释策略。现在,后基因组科学正在成为理解生物学,基因与环境之间以及物种与空间之间的关系,开拓未来可能性和不同的生活方式的方法。本文探索了一种形式的后基因组研究的新出现的拓扑结构和时间性,它借鉴了国际人种学研究功能基因组学的国际成果,这些研究正在使用突变小鼠来了解哺乳动物的基因功能。我使用德里达和哈拉威的怪兽词汇,提出生物学中怪兽的另一种概念化,其中功能基因组学中小鼠的优势一直是基因组学还原论语法的不断补充。这种形式的功能基因组学,不是在寻找事物的最低限度本质,而是成为实验性,物质性和情感性生物过剩和过剩的产生和组织中的一种练习。在这种情况下,怪物的不确定功能会成为科学家和社会科学家的生成催化剂,从而激增了人们聆听并参与变异基因,生活形式和后基因组生物学语言的观点。

著录项

  • 来源
    《Geoforum》 |2013年第8期|268-278|共11页
  • 作者

    Gail Davies;

  • 作者单位

    College of Life and Environmental Sciences, University of Exeter Amory Building, Rennes Drive, Exeter, EX4 4RJ, United Kingdom;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Monstrosity; Excess; Complexity; Mutant mice; Genetics; Functional genomics;

    机译:怪物;过量;复杂;突变小鼠;遗传学功能基因组学;
  • 入库时间 2022-08-18 03:36:27

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