Linkage Maps of the dwarf and Normal Lake Whitefish (Coregonus clupeaformis) Species Complex and Their Hybrids Reveal the Genetic Architecture of Population Divergence

摘要

Elucidating the genetic architecture of population divergence may reveal the evolution of reproductivenbarriers and the genomic regions implicated in the process. We assembled genetic linkage maps for thendwarf and Normal lake whitefish species complex and their hybrids. A total of 877 AFLP loci and 30nmicrosatellites were positioned. The homology of mapped loci between families supported the existencenof 34 linkage groups (of 40n expected) exhibiting 83% colinearity among linked loci between these twonfamilies. Classes of AFLP markers were not randomly distributed among linkage groups. Both AFLP andnmicrosatellites exhibited deviations from Mendelian expectations, with 30.4% exhibiting significantnsegregation distortion across 28 linkage groups of the four linkage maps in both families (P , 0.00001).nEight loci distributed over seven homologous linkage groups were significantly distorted in both familiesnand the level of distortion, when comparing homologous loci of the same phase between families, wasncorrelated (Spearman R ¼ 0.378, P ¼ 0.0021). These results suggest that substantial divergence incurrednduring allopatric glacial separation and subsequent sympatric ecological specialization has resulted innseveral genomic regions that are no longer complementary between dwarf and Normal populations issuednfrom different evolutionary glacial lineages.