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Association Analysis Between the Prostaglandin E Synthase 2 R298H Polymorphism and Body Mass Index in 8079 Participants of the KORA Study Cohort

机译:KORA研究队列中8079名参与者的前列腺素E合酶2 R298H多态性与体重指数之间的关联分析

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Context: The H-allele of the R298H polymorphism in the prostaglandin E synthase 2 (PTGES2) gene was associated with lower risk of diabetes type 2. Aim: To explore the association between the PTGES2 R298H SNP and body mass index (BMI). Methods: We analyzed the R298H SNP (rsl3283456) and three haplotype single-nucleotide polymorphisms (rs884115, rsl0987883, and rs4837240) covering a 20 kb gene region in population-based surveys of the Kooperative Gesundheitsforschung in der Region Augsburg study cohort with 8079 participants. Results: A statistically significant difference in BMI between the heterozygous PTGES2 R298H genotype and the homozy-gous R/R genotype was found in males but not in females. Males with the R/H genotype showed a decrease in BMI of -0.30 BMI units (95% CI: -0.55, -0.04, p = 0.02) in comparison to R/R males. A haplotype comprising the minor allele of PTGES2 R298H showed a significant decrease of -0.23 BMI units in males (-0.45, -0.02; p = 0.04) but not in females. Other haplotypes and haplotype single-nucleotide polymorphisms were not significantly associated with BMI. Conclusion: We found a marginal but significant influence of the PTGES2 298H SNP on BMI in a large population-based study.
机译:背景:前列腺素E合酶2(PTGES2)基因中R298H多态性的H等位基因与2型糖尿病风险较低相关。目的:探讨PTGES2 R298H SNP与体重指数(BMI)之间的关系。方法:我们在奥格斯堡地区有8079名参与者进行的基于Koge Gesundheitsforschung合作研究的人群调查中,分析了R298H SNP(rsl3283456)和三个单倍型单核苷酸多态性(rs884115,rsl0987883和rs4837240),覆盖了20 kb基因区域。结果:杂合PTGES2 R298H基因型和纯合R / R基因型之间的BMI差异有统计学意义。与R / R男性相比,具有R / H基因型的男性BMI降低了-0.30 BMI单位(95%CI:-0.55,-0.04,p = 0.02)。包含PTGES2 R298H的次要等位基因的单倍型在男性中显着降低-0.23 BMI单位(-0.45,-0.02; p = 0.04),而在女性中则没有。其他单倍型和单倍型单核苷酸多态性与BMI无关。结论:在一项基于人群的大型研究中,我们发现PTGES2 298H SNP对BMI的影响微乎其微。

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  • 来源
    《Genetic Testing》 |2009年第2期|223-226|共4页
  • 作者单位

    Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrecht-University, Kiel, Germany;

    Institute of Epidemiology, German Research Centre for Environmental Health, Helmholtz Centre, Munich, Germany;

    Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrecht-University, Kiel, Germany;

    Institute of Epidemiology, German Research Centre for Environmental Health, Helmholtz Centre, Munich, Germany;

    Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrecht-University, Kiel, Germany;

    Institute of Epidemiology, German Research Centre for Environmental Health, Helmholtz Centre, Munich, Germany;

    Institute of Epidemiology, German Research Centre for Environmental Health, Helmholtz Centre, Munich, Germany;

    Department of Molecular Prevention Institute for Human Nutrition and Food Science Christian-Albrecht-University, Kiel Heinrich-Hecht-Platz 10 24118 Kiel Germany;

    Institute of Epidemiology, German Research Centre for Environmental Health, Helmholtz Centre, Munich, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:21:27

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