Investigation of KIF6 Trp719Arg in a Case-Control Study of Coronary Artery Disease in Western Indians

摘要

Background: A single-nucleotide polymorphism Trp719Arg (rs20455T>C) in the kinesin-like protein 6 (KIF6), which is a protein involved in intracellular transport, has been shown to predict increased coronary artery disease (CAD) risk and event reduction during statin therapy. Aim: In the current study, we have evaluated the association of the variant Trp719Arg with CADon fatal myocardial infarction (MI) in Western Indians. Methods: Genotyping for Trp719Arg was done by an allele-specific real-time assay in 227 cases with confirmed CAD and 150 controls. Results: We have found that the KIF6 719 Arg carriers were not at a significantly higher risk for CADon-fatal MI in this case-control study of an Indo-European population from Western India (Unadjusted odds ratio [OR] 0.767 95% confidence interval [CI] 0.573-1.027 for 719Arg carriers). When the genotypes were further tested to determine association with prevalent myocardial infarction as the event versus CAD, no association was seen in a univariate analysis (MI vs. CAD OR 0.804 95% CI 0.543-1.189; MI vs. Controls OR 0.702 95% CI 0.482-1.021). Conclusion: In summary, carriers of the KIF6 719Arg allele were not at increased risk of CADon-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.