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首页> 外文期刊>Genetic testing and molecular biomarkers >Apollpoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis
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Apollpoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

机译：载脂蛋白A5基因多态性和代谢综合征的风险：荟萃分析。

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摘要

Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). However, these studies drew inconsistent conclusions. The aim of this study was to evaluate the exact association between the ApoA5 polymorphism and MetS in a large-scale meta-analysis. Methods: The PubMed, Embase, and Science Citation Index (ISI Web of Science) databases were searched to collect all publications on the association between the ApoA5 polymorphism and MetS. Two common variants of ApoA5 (namely - 1131T>C in the promoter region and C.56C >G in the coding region) with the risk of MetS were analyzed. The overall odd ratios (ORs) and 95% confidence intervals (CIs) for -1131T>C (CC + TC) versus TT genotype and C.C56G (GG+GC) versus CC were assessed between the MetS and control group. Subgroup analysis was further performed by ethnicity. The meta-analysis was performed by Stata11.0. Results: Twelve studies from 10 publications were chosen in our meta-analysis. The combined results showed that C allele carriers (CC+TC) of -1131T>C had a significantly higher risk of MetS for the overall (OR=1.32; 95% CI: 1.14-1.53; p = 0.000) with moderate heterogeneity (I2 = 54.9%, p=0.014). Subgroup analysis was further performed according to ethnicity, and the association was still significant in Asians (OR=1.42; 95% CI: 1.25-1.62; p=0.000), but not in white populations (OR=1.25; 95% CI: 0.97-1.61; p = 0.087). When analyzing the association between C.C56G and MetS, the G allele carrier (GG+GC) genotype significantly increased the risk of MetS (OR=1.32; 95% CI: 1.15-1.50; p = 0.000) in white populations. No significant publication bias was observed in either -1131T>C or C.C56G. Conclusions: Our study suggested that the ApoA5 -1131T>C polymorphism was significantly associated with the risk of MetS in Asians, but not in white populations. However, the C.C56G polymorphism was significantly associated with MetS in white populations.
机译：许多研究集中在载脂蛋白A5（ApoA5）多态性与代谢综合征（MetS）的风险之间的关联上。但是，这些研究得出了不一致的结论。这项研究的目的是在大规模的荟萃分析中评估ApoA5多态性与MetS之间的确切关联。方法：检索PubMed，Embase和科学引文索引（ISI Web of Science）数据库，以收集有关ApoA5多态性与MetS之间关联的所有出版物。分析了ApoA5的两个常见变体（即启动子区域中的1131T> C和编码区域中的C.56C> G）具有MetS的风险。在MetS和对照组之间评估了-1131T> C（CC + TC）与TT基因型以及C.C56G（GG + GC）与CC的总奇数比（OR）和95％置信区间（CI）。按种族进一步进行亚组分析。荟萃分析由Stata11.0进行。结果：在我们的荟萃分析中选择了10个出版物中的12个研究。合并结果显示，-1131T> C的C等位基因携带者（CC + TC）具有总体MetS的较高风险（OR = 1.32； 95％CI：1.14-1.53​​； p = 0.000），中等异质性（I2 = 54.9％，p = 0.014）。根据种族进一步进行了亚组分析，该关联在亚洲人中仍然很显着（OR = 1.42； 95％CI：1.25-1.62； p = 0.000），而在白人人群中则没有（OR = 1.25； 95％CI：0.97） -1.61； p = 0.087）。分析C.C56G与MetS之间的关联时，G等位基因携带者（GG + GC）基因型显着增加了白人人群中MetS的风险（OR = 1.32； 95％CI：1.15-1.50； p = 0.000）。在-1131T> C或C.C56G中均未观察到明显的出版偏倚。结论：我们的研究表明，ApoA5 -1131T> C基因多态性与亚洲人的MetS风险显着相关，而在白人人群中则没有。但是，C.C56G多态性与白人人群中的MetS显着相关。

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  • 来源
    《Genetic testing and molecular biomarkers》 |2012年第10期|1241-1245|共5页
  • 作者

    Cun-Fei Liu; Qun-Fang Yang; Xing-Lin Chen; Cheng-Yun Liu;

  • 作者单位

    Departments of Geriatrics and Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China;

    Hyperbaric Oxygen Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China;

    Departments of Geriatrics and Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China;

    Department of Geriatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province 430022 P.R. China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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