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Helicobacter pylori Infection and MDM2 SNP309 Association with Gastric Cancer Susceptibility

机译:幽门螺杆菌感染和MDM2 SNP309与胃癌易感性的关系

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Aims: MDM2 is a negative regulator of p53, and has also been implicated in carcinogenesis. The aim of this study was to define the causal association of Helicobacter pylori infection and the MDM2 SNP309 among northern Iranian patients with gastric cancer (GC). Two hundred and eight patients with GC and 200 cancer-free controls were genotyped for MDM2 SNP309 using the polymerase chain reaction-restriction fragment length polymorphism method. The ureC (glmM) gene was used for detection of H. pylori in this study. Results: The G allele was found more frequently among patients with GC (55%) than among controls (37%). The risk of GC for MDM2 309G/G genotypes was considerably increased when compared with TT genotypes (odds ratio [OR] = 15.93,95% confidence interval [CI]=4.17-60.84). Among H. pylori-infected subjects, a significantly increased risk of GC associated with the GG genotype was quite clear (OR=14.66, 95% CI=3.54-60). Conclusions: The GG genotype was associated with an increased risk of gastric carcinoma. We also found that there is a joint effect of MDM2 SNP309G/G genotype and H. pylori infection for the development of gastric carcinoma. However, the findings need to be verified in large population-based prospective studies for more rigorous analyses of subgroups and gene-environment and gene-gene interactions.
机译:目的:MDM2是p53的负调节剂,也与致癌作用有关。这项研究的目的是确定伊朗北部胃癌(GC)患者中幽门螺杆菌感染与MDM2 SNP309的因果关系。使用聚合酶链反应-限制性片段长度多态性方法对208例GC患者和200例无癌对照进行MDM2 SNP309基因分型。在本研究中,使用ureC(glmM)基因检测幽门螺杆菌。结果:GC患者中的G等位基因(55%)比对照组(37%)更为常见。与TT基因型相比,MDM2 309G / G基因型的GC风险显着增加(赔率[OR] = 15.93,95%置信区间[CI] = 4.17-60.84)。在幽门螺杆菌感染的受试者中,与GG基因型相关的GC风险显着增加(OR = 14.66,95%CI = 3.54-60)。结论:GG基因型与胃癌风险增加有关。我们还发现,MDM2 SNP309G / G基因型和幽门螺杆菌感染对胃癌的发展具有联合作用。但是,需要对基于人群的前瞻性研究中的发现进行验证,以对亚组以及基因环境和基因-基因相互作用进行更严格的分析。

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  • 来源
    《Genetic testing and molecular biomarkers》 |2013年第11期|794-798|共5页
  • 作者单位

    Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran;

    Department of Biology Faculty of Sciences University of Guilan Rasht 1914 Iran;

    Guilan University of Medical Sciences (GUMS), Rasht, Iran;

    Guilan University of Medical Sciences (GUMS), Rasht, Iran;

    Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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  • 入库时间 2022-08-17 13:17:39

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