The Influence of g.19124G＞A Genetic Polymorphism in the OPG Gene on Bone Mineral Density in Chinese Women

摘要

Objective: The aim of this study was to detect the influence of g.l9124G＞A genetic polymorphism in the osteo-protegerin (OPG) gene on bone mineral density (BMD) and osteoporosis in Chinese postmenopausal women. Methods: A total of 403 primary osteoporosis subjects and 409 healthy controls were enrolled in this study. The BMD value of the femoral neck hip, lumbar spine (L_(2-4)), and total hip was analyzed by Norland XR-46 dual energy X-ray absorptiometry. The polymerase chain reaction-restriction fragment length polymorphism method was utilized to investigate the genotype of g.l9124G＞A genetic polymorphism. Results: We found significant differences of the femoral neck hip, lumbar spine (L_(2-4)), and total hip of BMD among different genotypes of g.l9124G＞A genetic polymorphism, individuals with the genotype GG had significantly higher BMD than those of genotype GA and AA (p＜0.05). Conclusion: These findings indicate that the g.l9124G＞ A genetic polymorphism in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women, and the allele A could be associated with a lower BMD and an increased risk factor for osteoporosis.