Vitamin D Receptor Gene Bsml and Fokl Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population;

摘要

Background: The role of vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) in ovarian cancer has been studied in various populations; however, these results are discordant between different ethnicities. Method: Using the polymerase chain reaction-restriction fragment length polymorphism method, we studied the prevalence of the VDR FokI (rs2228570) and Bsml (rsl544410) SNPs in women with ovarian cancer (n = 168) and controls (n = 182) in a Polish population. Results: We found a significant contribution of the BsmI SNP Bb + BB-versus-bb dominant inheritance model to ovarian cancer development (p=0.0221, pcorr=0.0442, odds ratio [OR] = 1.648 [95% confidence intervals, CI = 1.073-2.532]). However, we did not observe an association of the Bsml SNP BB versus Bb+bb recessive inheritance model in patients (p = 0.8059, OR=1.093 [95% CI = 0.538-2.218]). Moreover, there was no association of Fokl SNPs either in Ff+ff versus FF dominant or ff versus Ff+FF recessive inheritance models with ovarian cancer development (p = 0.9924, OR=1.002 [95% CI = 0.628-1.599] and p=0.1123, OR=1.542 [95% CI =0.901-2.638], respectively). The p-values of the trend test observed for the VDR Bsml and Fokl SNPs in patients with ovarian cancer were ptrend = 0.0613 and ptrend = 0.3655, respectively. Conclusion: Our study indicates that the VDR B gene variant might be a moderate risk factor of ovarian cancer development in the Polish population.