Association Between the c.3073A＞C Genetic Polymorphism of the MDR1 Gene and Susceptibility to Gastric Cancer in the Chinese Han Population

摘要

Objective: Gastric cancer is one of the most common malignancies in the world. The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing the susceptibility to gastric cancer. The objective of this study was to find out the association of MDR1 genetic variants with gastric cancer susceptibility in the Chinese Han population. Methods: In total, 375 gastric cancer patients and 378 cancer-free controls were included. The c.3073A ＞ C genetic polymorphism of the MDR1 gene was genotyped by the polymerase chain reaction-restriction fragment length polymorphism method. Results: We found that the genotypes/alleles from c.3073A＞C genetic polymorphisms were statistically associated with gastric cancer risk. The risk of gastric cancer was significantly higher for the CC genotype as compared to the AA wild genotype (odds ratio [OR] = 1.85,95% confidence interval [CI] 1.15-2.97, p=0.010). The allele C may contribute to the susceptibility to gastric cancer (OR=1.37,95% CI 1.10-1.70, p=0.005). Conclusion: These preliminary results indicate that the c.3073A＞C genetic polymorphism of the MDR1 gene is potentially related to the susceptibility to gastric cancer in the Chinese Han population.