Underlying mechanisms of short-term synaptic plasticity at identified central synapses

摘要

The general goal of my project was to detect the underlying mechanisms of short-term plasticity at identified synapses in the central nervous system. I have investigated the bases of cell type-specific differences in short-term plasticity of synaptic connections of distinct types of hippocampal interneu-rons. My results showed that both the overall strength and the short-term plasticity of synapses received and established by hippocampal interneu-rons are highly regulated by persistently active presynaptic metabotropic receptors in a cell type-specific manner. Thus, in principle, cell type-specific modulation of short-term plasticity by toni-cally active presynaptic receptors may contribute to the differential functional role of distinct in-terneurons during normal and pathological hippocampal functioning.