Genetics of systemic lupus erythematosus

摘要

Systemic lupus erythematosus remains a disease with an elusive etiology, and the search for genetic factors that trigger the autoimmune cascade has only been accelerated by recent advances in technology. Starting with the early observations that HLA type and complement deficiency had an impact on disease risk, genetic studies in lupus have now expanded to include genome-wide linkage and association scans, as well as hypothesis-driven candidate gene studies on nearly 200 different genetic loci. This review will classify the existing literature and report on the genes that most consistently contribute to systemic lupus erythematosus risk.