Toxicokinetics in infants and children in relation to the ADI and TDI

摘要

Age-dependent developmental changes in toxicokinetics occur in both rats and humans, particularly in relation to renal function and hepatic xenobiotic metabolism. These processes are immature in humans at birth, Especially in the pre-term neonate, but mature rapidly Over the first months of life. In consequence the Duration of immaturity primarily corresponds to the Period of suckling. Similar developmental changes Occur in the neonatal rat over the first weeks of life.