Replication of Enterotropic and Polytropic Murine Coronaviruses in Cultured Cell Lines of Mouse Origin

摘要

To understand the virus-cell interactions that occur during murine coronavirus infection, six murine cell lines(A3-1M, B16, CMT-93, DBT, 1C-21 and J774A. 1)were inoculated with eight murine coronaviruses, including prototype strains of both polytropic and enterotropic biotypes, and new isolates. All virus strains produced a cytopathic effect (CPE)with cell-to-cell fusion in B16, 1C-12 and J744A. 1 cells.