Characterization of Hyperinsulinemic Recombinant Inbred (RI)Strains(SMXA-5 and SMXA-9)Derived from Normoinsulinemic SM/J and A/J Mice

摘要

We discovered two mouse strains(SMXA-5 and SMXA-9) with hyperinsulinemia among the substrains and progenitor strains(SM/J and A/J)of the SMXA recombinant inbred(RI)strains, and characterized the two strains at 20 weeks of age. SMXA-5(mean± S.E.M: 9.6±1.7 ng/ml)and SMXA-9(7.7±1.3ng/ml)males had higher serum Immunoreactive insulin levels than SM/J(1.4±0.3 ng/ml)and A/J(1.1±0.1 ng/ml)males in The nonfasting condition.