Blunt Cell Growth Potential in Carcinogen Resistant Inbred DRH Rats

摘要

A carcinogen-resistant inbred strain DRH/Sea has been developed from the Crj: Donryu strain. The rats had a very low incidence of liver tumors when they were fed Diets containing a hepatocarcinogen such as 3'-methyl-4-dimethylamino-azobenzene(3'- Me-DAB). Despite using 3'-Me-DAB during the stage of selection, the DRH/Sea rats Developed normally, reproduced and did not have any spontaneous tumor in the lung, liver Or uterus at over 1 year of age.