Microbiological Contamination in Genetically Modified Animals and Proposals for a Microbiological Test Standard for National Universities in Japan

摘要

The Biosafety Committee of the Japanese Association of Laboratory Animal Facilities of National Universities (JALAN) investigated recent episodes of microbiological Contamination in genetically modified mice (GMM), and the countermeasures taken when the Contaminated GMM were introduced into animal facilities, by questionnaires addressed to 53 Animal facilities belonging to JALAN and serological tests. Although almost all of the Contaminated GMM were accepted with conditions such as rederivation after or before Reception and housing in designated rooms, contamination with a spectrum of Microorganisms was demonstrated in GMM transferred domestically and from abroad.