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Quantitative Trait Loci for Glomerulosclerosis, Kidney Weight and Body Weight in the Focal Glomerulosclerosis Mouse Model

机译:局灶性肾小球硬化小鼠模型中肾小球硬化,肾脏重量和体重的定量性状位点

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In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.
机译:在FGS / Kist品系,人类局灶性肾小球硬化症(FGS)的新小鼠模型和标准正常品系C57BL / 6J之间回交的183个雄性子代中,我们进行了全基因组扫描以检测数量性状基因座(根据组织学观察以及肾脏和体重,QTLs影响肾小球硬化指数(GSI)。在全基因组5%处检测到位于染色体8和10上的两个GSI Qsi(Gsi1-2),位于Chr 19上的肾脏QTL(Kdw1)和位于Chr 13上的体重QTL(Bdw1)。或更低的水平。来自FGS / Kist的等位基因在Gsi1处增加GSI,而在Gsi2处降低。 FGS / Kist等位基因纯合的小鼠降低了体重和肾脏重量。鉴定出的QTL占表型变异的5-8%。

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