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Comparison of Rat Mandible Bone Characteristics in F344 Substrains, F344/Du and F344/N

机译:F344亚种F344 / Du和F344 / N中大鼠下颌骨特征的比较

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The characteristics of the mandible bone were compared through DXA methods between two major substrains of F344 rats, F344/DuCrlCrlj and F344/NSIc at around 60 days of age. Since these two substrains are clearly different in survival and mandible morphology, some genetic differences are supposed to exist. In contrast to a previous microsatellite analysis, clear and significant differences were detected in the body and mandible weights, the mandible bone mineral contents (BMC), bone area (AREA), bone mineral density (BUD) and bone mineral ratio (BMR), between F344/DuCrlCrlj and F344/ NSIc, with the mandible molar teeth intact in the bone. Thus, care is needed in the experimental use of these substrains, as results may differ between them. The newly proposed parameter, BMR, may especially contribute to the comparison of bone characteristics among species.
机译:通过DXA方法在60天左右的F344大鼠的两个主要亚种F344 / DuCrlCrlj和F344 / NSIc之间比较了下颌骨的特征。由于这两个亚种在存活率和下颌骨形态上明显不同,因此应该存在一些遗传差异。与先前的微卫星分析相比,在人体和下颌骨重量,下颌骨矿物质含量(BMC),骨面积(AREA),骨矿物质密度(BUD)和骨矿物质比率(BMR)中发现了明显且显着的差异, F344 / DuCrlCrlj和F344 / NSCc之间,下颌臼齿在骨骼中完整无缺。因此,在实验中使用这些亚菌株时需要小心,因为它们之间的结果可能有所不同。新提出的参数BMR可能特别有助于物种间骨骼特征的比较。

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