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Experimental Adhesion Model: Effect of Viscosities of Fluids Put in the Peritoneal Cavity on Preventing Peritoneal Adhesions

机译:实验性粘连模型:腹膜腔内液体粘度对预防腹膜粘连的影响

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In this study we assessed the effectiveness of fluid viscosities placed in the peritoneal cavity to prevent postoperative peritoneal adhesions. Thirty-six Wistar albino female rats (average weight: 160 ± 30 g, average age: 6.5 months) were divided into three groups of equal number. A standard adhesion pattern was formed in each group. Then, 3 ml isotonic sodium chloride solution (relative viscosity value: 1) was added into the peritoneal cavity of group 1; 3 ml standard 6% hydroxy ethyl starch solution (HES) (relative viscosity value: 2.9) was added into the peritoneal cavity of group 2; and a standard HES solution that was concentrated by dehydration (relative viscosity value: 249.7) was added into the peritoneal cavity of group 3. All rats were sacrificed on postoperative day 10 and the adhesions that formed were graded. In group 1, grade-3 adhesions developed in 9 (75%) rats, and grade-2 developed in 3 (25%) rats. In group 2, grade-3 adhesions developed in 1 (8.3%) rat, grade-2 developed in 6 (50%) rats, and grade-1 developed in 5 (41.6%) rats; in group 3, grade-3 adhesions developed in 9 (75%) rats, and grade-2 developed in 3 (25%) rats. The adhesion scores of group 3 and group 1 were equal to each other (P=1), while the adhesion score of group 2 was significantly less (χ~2:18.23, P < 0.001). Increasing the viscosity of fluids that are inserted in the peritoneal cavity may reduce the formation of postoperative peritoneal adhesions till a critical value of unknown viscosity is achieved. The mechanism behind this process remains unclear.
机译:在这项研究中,我们评估了放置在腹膜腔内的液体粘度防止术后腹膜粘连的有效性。将三十六只Wistar白化病雌性大鼠(平均体重:160±30 g,平均年龄:6.5个月)分为三组,每组相等。在每个组中形成标准的粘附图案。然后,将3ml等渗氯化钠溶液(相对粘度值:1)加入第1组的腹膜腔中;将3ml标准的6%羟乙基淀粉溶液(HES)(相对粘度值:2.9)加入第2组的腹膜腔中;然后将通过脱水浓缩的标准HES溶液(相对粘度值:249.7)添加到第3组的腹膜腔中。在术后第10天处死所有大鼠,并对形成的粘连进行分级。在第1组中,在9(75%)只大鼠中发生了3级粘连,而在3(25%)只大鼠中发生了2级粘连。在第2组中,1只(8.3%)大鼠发生3级粘连,6只(50%)大鼠发生2级粘连,5只(41.6%)大鼠发生1级粘连。在第3组中,在9(75%)只大鼠中发生了3级粘连,而在3(25%)只大鼠中发生了2级粘连。第3组和第1组的粘附力得分彼此相等(P = 1),而第2组的粘附力得分则显着降低(χ〜2:18.23,P <0.001)。增加插入腹膜腔内的液体的粘度可能会减少术后腹膜粘连的形成,直到达到未知粘度的临界值为止。该过程背后的机制仍不清楚。

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