Histological Characteristics of Respiratory System in Brown Norway Rat

摘要

It is well known that the Brown Norway (BN) rat strain exhibits airway hyperresponsiveness to exposure to allergens or some chemicals. We investigated the histological characteristics of the trachea and lungs of this strain (10-week-old and retired animals) and compared them with those of age-matched Fisher 344 (F344) rat strain. No histological differences between two strains in tracheal epithelial cells were detected, but differences in the distribution and development of submucosal glands were clarified by the observation of serial sections cut at intervals of 100 μm.