Heredity of Red Blood Cells with High K and Low Glutathione (HK/LG) and High K and High Glutathione (HK/HG) in a Family of Japanese Shiba Dogs

摘要

Forty-two of 81 dogs from a family of Japanese Shiba dogs had red blood cells with a high K and a low Na concentration (HK). Of the HK dogs, 32 were high K and low glutathion (HK/LG) and 10 were high K and high glutathione (HK/HG). These variants were found in both males and females. The phenotype of HK was inherited in a recessive mode as reported earlier. A high incidence of HK/LG dogs was found in this family, and the phenotype was also inherited in a recessive mode. Glutamate (Glu) influx, which defines the cellular glutathione concentration, was lower in HK/LG cells than in HK/HG cells (in some cases extremely low).