Efficacy of 6-chloro-2', 3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS Rhesus macaque (Macaca mulatta) Infected with Simian Immunodeficiency Virus

摘要

The efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) was investigated in vivo by using a male ARC/AIDS rhesus macaque infected with simian immunodeficiency virus (SIV mac251/32H). He was administered subcutaneously 6-Cl-ddG (50 mg/kg B. W.) every 8 hr for 14 days when he showed clinical features of recurrent weight loss, severe diarrhea and neuropathy. The number of CD4~+, CD8~+ cells and total T cells increased rapidly after administration of 6-Cl-ddG and a high level was maintained for 2 months, but the B cell count decreased during the treatment.