Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys

摘要

Age-relaed changed in major lymphocyte subsets were analyzed in 195 cynomolgus monkeys (Macaca fascicularis) aged form one month to 31 years. The percentages of CD20+ B cells in peripheral blood lymphocytes (PBL) decreased with age to five years of age, but after that, no significant change was observed. The percentages of CD16+ NK cells gradually increased during the first five years and reached the peak at from Four to ten years of age, whereas the percentages of CD3+ T cells in PBL were relatively Constant throughout the life.