A Rhino Mutant Originating in KK Mice

摘要

In 1991, several hairless offspring were found in our black haired KK (KK-C) mouse colony. This mutant provisionally naming KK-rhino mouse was clinicopathologically and histopathologically investigated in a chronological manner. KK-rhino has a hairless trait and wrinkled and pimpled skin, which resemble the characteristics of the so-called rhino mouse. It was presumed from a preliminary mating examination that the trait of the KK- rhino mutatn might be manifested by the [hr~rh] gene.