Histamine-Induced Airway Contraction in Congenitally bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs

摘要

Airway hyper-responsiveness is known as an important pathogenesis of asthma. In the present study, the airway responsiveness to aerosolized and injected histamine in Congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs Was investigated. In addition, the role of the vagal reflux in histamine-induced airway Contraction was evaluated by vagal blocking with atropine inhalation or bilateral vagotomy. A Significatly higher bronchoconstrictive reaction, i.e., a decrease in tidal volume (V_T) and an Increase in respiratory resistance (Rrs), to histamine-inhalation was observed in BHS than in BHR.