Strain Differences of Hypertension Induced by Dietary N~G-nitro-L-arginine in Normotensive Rats

摘要

When the potent inhibitor of nitic oxide (NO) synthesis N~G-nitro-L-arginine (L- NNA) was incorporated into the diet, hypertension was induced and sustained due to the Effects of the long-term inhibition of endothelium-dependent relaxing factor (EDRF)/NO. The effects of L-NNA on normotensive rats of four strains (Donryu, Sprague-Dawley (SD), Wistar, and Wistar-Kyoto (WKY) were compared relative to control rats.