Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

Hideaki Kagaya; Kazuyuki Inoue; Masatomo Miura; Shigeru Satoh; Mitsuru Saito; Hitoshi Tada; Tomonori Habuchi; Toshio Suzuki

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Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

机译：UGT1A8和UGT2B7基因多态性对日本肾移植受者麦考酚酸药代动力学的影响

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摘要

UGT1A8 and UGT2B7 are important uridine diphosphate-glucuronosyltransferase isoforms for the glucuronidation of mycophenolic acid (MPA). The aim of this investigation was to elucidate MPA pharmacokinetics in UGT1A8 and UGT2B7 genotypes in Japanese renal transplant recipients.

机译：UGT1A8和UGT2B7是用于霉菌酚酸（MPA）葡萄糖醛酸化的重要尿苷二磷酸-葡萄糖醛酸转移酶同工型。这项研究的目的是阐明日本肾移植受者中UGT1A8和UGT2B7基因型的MPA药代动力学。

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来源
《European Journal of Clinical Pharmacology》 |2007年第3期|279-288|共10页
作者
Hideaki Kagaya; Kazuyuki Inoue; Masatomo Miura; Shigeru Satoh; Mitsuru Saito; Hitoshi Tada; Tomonori Habuchi; Toshio Suzuki;
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作者单位

Department of Pharmacy Akita University Hospital 1-1-1 Hondo Akita 010-8543 Japan;

Department of Pharmacy Akita University Hospital 1-1-1 Hondo Akita 010-8543 Japan;

Department of Pharmacy Akita University Hospital 1-1-1 Hondo Akita 010-8543 Japan;

Department of Urology Akita University School of Medicine Akita Japan;

Department of Urology Akita University School of Medicine Akita Japan;

Department of Pharmacy Akita University Hospital 1-1-1 Hondo Akita 010-8543 Japan;

Department of Urology Akita University School of Medicine Akita Japan;

Department of Pharmacy Akita University Hospital 1-1-1 Hondo Akita 010-8543 Japan;

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正文语种 eng
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关键词
Mycophenolic acid; UGT1A8; UGT2B7; Polymorphism; Kinetics;

机译：麦考酚酸;UGT1A8;UGT2B7;多态性;运动学;

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专利

1. Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. [J] . Kagaya H, Inoue K, Miura M, European journal of clinical pharmacology . 2007,第3期

机译：UGT1A8和UGT2B7遗传多态性对日本肾移植受者中麦考酚酸药代动力学的影响。
2. Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. [J] . Fujiyama N, Miura M, Satoh S, Xenobiotica: the fate of foreign compounds in biological systems . 2009,第5期

机译：羧酸酯酶2遗传多态性对日本肾移植受者中麦考酚酸药代动力学的影响。
3. Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. [J] . Inoue K, Miura M, Satoh S, Therapeutic Drug Monitoring . 2007,第3期

机译：UGT1A7和UGT1A9内含子I399基因多态性对日本肾移植接受者中麦考酚酸药代动力学的影响。
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

机译：CYP3A4 * 18B多态性与中国肾移植患者滑石M药代动力学的关系
5. The pharmacokinetics and pharmacodynamics of mycophenolic acid in kidney transplant recipients. [D] . Patel, Chirag G. 2006

机译：麦考酚酸在肾移植受者中的药代动力学和药效学。
6. Mycophenolic acid AUC in Thai kidney transplant recipients receiving low dose mycophenolate and its association with UGT2B7 polymorphisms [O] . Manop Pithukpakorn, Tiwat Tiwawanwong, Yupaporn Lalerd, 2014

机译：低剂量麦考酚酸酯的泰国肾脏移植受者中的麦考酚酸AUC及其与UGT2B7多态性的关系
7. UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients [O] . Tsuyoshi Fukuda, Jens Goebel, Shareen Cox, 2012

机译：UGT1A9，UGT2B7和MRP2基因型可以预测儿科肾移植受者的霉硫酸药代动力学变异性

Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

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