Comparative developmental dermal toxicity and mutagenicity of carbazole and benzo[a]carbazole

摘要

The objectives of this study were (1) to determine the developmental toxicity of carbazole and benao [a] carbazole following daily dermal administration to female Sprague-Dawley rats on days 0 through 20 of gestation and (2) to determine the mutagenicity of these two compounds using a modified version of the Ames assay. These chemicals are of concern because they are found in a variety of environmental matrices including crude oil mixtures. No signs of maternal or developmental toxicity were considered to be related to dermal administration of carbazole at doses of 2.5, 25.0 mg/kg.