首页> 外文期刊>Environmental Toxicology and Chemistry >REPRODUCTIVE EFFECTS OF HEXAHYDRO-1,3,5-TRINITROSO-1,3,5-TRIAZINE IN DEER MICE (PEROMYSCUS MANICULATUS) DURING A CONTROLLED EXPOSURE STUDY
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REPRODUCTIVE EFFECTS OF HEXAHYDRO-1,3,5-TRINITROSO-1,3,5-TRIAZINE IN DEER MICE (PEROMYSCUS MANICULATUS) DURING A CONTROLLED EXPOSURE STUDY

机译:受控暴露研究过程中六乙-1,3,5-三氮杂1,3,5-三嗪对鹿小鼠的繁殖作用

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摘要

Contamination with hexahydro-1,3,5-trinitro-1,3,5-triazine (Royal Demolition Explosive [RDX]) has been identified at areas of explosive manufacturing, processing, storage, and usage. Thus, the potential exists for exposure to N-nitroso compounds, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine, hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine, and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), formed via anaerobic transformation of RDX. Following exposure, reproductive toxicity of TNX was evaluated in three consecutive litters of deer mice (Peromyscus maniculatus). Hexahydro-1,3,5-trinitroso-1,3,5-triazine was administered ad libitum via drinking water at four doses: 0 (control), 1, 10, and 100 μg/L. Endpoints investigated included reproductive success, offspring survival, offspring weight gain, offspring organ weights, and liver TNX residues. Data from the present study indicate that TNX bioaccumulates in the liver and is associated with postpartum mortality, dose-dependent decrease in body weight from birth to weaning, and decrease in kidney weight of deer mice offspring.
机译:在炸药的生产,加工,储存和使用领域,已经发现六氢-1,3,5-三硝基-1,3,5-三嗪(皇家爆破炸药[RDX])的污染。因此,存在暴露于N-亚硝基化合物,六氢-1-亚硝基-3,5-二硝基-1,3,5-三嗪,六氢-1,3-二亚硝基-5-硝基-1,3,5的潜力。 -三嗪和六氢-1,3,5-三亚硝基-1,3,5-三嗪(TNX),是通过RDX的厌氧转化而形成的。暴露后,在连续三窝鹿小鼠(Peromyscus maniculatus)中评估了TNX的生殖毒性。通过饮用水随意给予六水-1,3,5-三亚硝基-1,3,5-三嗪,四种剂量:0(对照),1、10和100μg/ L。研究的终点包括生殖成功,后代存活,后代体重增加,后代器官重量和肝脏TNX残留物。来自本研究的数据表明,TNX在肝脏中生物蓄积并与产后死亡率,出生至断奶时体重的剂量依赖性降低以及鹿小鼠后代的肾脏重量降低有关。

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