Effects of 4,4 -dichloro-diphenyl diselenide (GlPhSe)_2 on toxicity induced by mercuric chloride in mice: A comparative study with diphenyl diselenide (PhSe)_2

摘要

The effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)_2 on the toxicity induced by mercuric chloride (HgCl_2) were investigated and compared with diphenyl diselenide (PhSe)_2. Mice received HgCl_2 for three days and, on the third day, received (PhSe)_2 or (ClPhSe)2. The results verified that the administration of (ClPhSe)2 in mice exposed to HgCl_2 increased renal 8-aminolevulinate dehydratase (5-ALA-D), Na~+, K~+-ATPase activities and non-protein thiol (NPSH) levels and also decreased thiobarbituric acid-reactive substances (TBARS) and ascorbic acid levels, when compared to mice exposed to HgCl_2 + (PhSe)_2. Plasma and urinary protein, hemoglobin and hematocrit levels and histological parameters were also ameliorated in mice exposed to HgCl_2 + (ClPhSe)_2. In addition, the hepatic damage in mice exposed to HgCl_2 + (PhSe)_2 was reduced in animals exposed to (ClPhSe)_2. To sum up, the introduction of a functional group (chloro) in the aromatic ring of diaryl diselenide reduced the toxicity of this compound in liver and kidney of mice exposed to HgCl_2.