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机译:NSCA-1-一种新型N取代香豆酰胺衍生物可通过调节Akt /GSK-3β信号传导和p53依赖的凋亡途径来提高HepG2 / adriamycin细胞中阿霉素的敏感性
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China,Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China;
Key laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Pharmaceutical Engineering, Shenyang 110016, China;
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China,Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China;
Key laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Pharmaceutical Engineering, Shenyang 110016, China;
Key laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Pharmaceutical Engineering, Shenyang 110016, China;
Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China;
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China,Key laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Pharmaceutical Engineering, Shenyang 110016, China;
N-Substituted coumalamide derivative; Adriamycin resistance; Akt; Apoptosis; P53; HepG2/ADR cells;
机译:人参皂甙Rh2辛基酯通过激活外在凋亡途径和调节Akt / p38 MAPK信号传导途径诱导人HepG2细胞凋亡和G1细胞周期阻滞
机译:通过mdr-1调节和Akt / mTOR信号转导,减少核磷素/ B23的表达可增加抗阿霉素的Molt-4白血病细胞的药物敏感性
机译:通过抑制PI3K / AKT信号通路抑制PI3K / AKT信号通路,硝酸尼氮唑逆转乳腺癌细胞对亚霉素的抵抗力
机译:肝癌细胞HepG2信号通路的构建及药物作用的鉴定
机译:通过激活PI3K / PDK / Akt信号转导途径,MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
机译:迷迭香酸联合阿霉素通过触发线粒体介导的HepG2和Bel-7402细胞的信号通路诱导凋亡。
机译:Nobiletin通过调节A549人非小细胞肺癌细胞的AKT /GSK3β/β-Catenin / Mycn / MRP1信号传导途径增强了对亚霉素的化学敏感性