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PCBs-high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice

机译:多氯联苯与高脂饮食之间的相互作用,作为雌性小鼠肠道菌群失调和腹部脂肪积累的媒介

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摘要

Polychlorinated biphenyls (PCBs), one type of lipophilic pollutant, are ubiquitous in daily life. PCBs exposure has been implicated in the alterations of gut microbial community which is profoundly associated with diverse metabolic disorders, including obesity. High-fat diet (H) is a dietary pattern characterized by a high percentage of fat. According to the theory that similarities can be easily solvable in each other, PCBs and H exposures are inevitably and objectively coexistent in a real living environment, prompting great concerns about their individual and combined effects on hosts. However, the effects of PCBs-H interactions on gut microbiota and obesity are still incompletely understood. In the present study, the effects of PCBs and/or H on the gut microbiota alteration and obesity risk in mice were examined and the interactions between PCBs and H were investigated. Obtained results showed that PCBs and/or H exposure induced prominent variations in the gut microbiota composition and diversity. Exposure to PCBs also resulted in higher body fat percentage, greater size of abdominal subcutaneous adipocytes and increased expression of proinflammatory cytokines including TNF-alpha, iNOS and IL-6. Such PCBs-induced changes could be further enhanced upon the co-exposure of H, implying that obese individuals may be vulnerable to PCBs exposure. Taken together, the present study is helpful for a better understanding of the gut microbiota variation influenced by PCBs and/or H exposure, and furthermore, provides a novel insight into the mechanism of PCBs-H interactions on host adiposity. (C) 2018 Elsevier Ltd. All rights reserved.
机译:多氯联苯(PCBs)是一种亲脂性污染物,在日常生活中无处不在。多氯联苯的暴露与肠道微生物群落的改变有关,而肠道微生物群落的改变与包括肥胖在内的各种代谢性疾病密切相关。高脂饮食(H)是一种以高百分比脂肪为特征的饮食模式。根据彼此之间可以轻松解决相似性的理论,PCB和H暴露在现实生活环境中不可避免且客观地共存,这引起了人们对它们各自和对宿主的综合影响的极大关注。然而,PCBs-H相互作用对肠道菌群和肥胖的影响仍未完全了解。在本研究中,研究了PCBs和/或H对小鼠肠道菌群变化和肥胖风险的影响,并研究了PCBs和H之间的相互作用。获得的结果表明,多氯联苯和/或氢暴露引起肠道菌群组成和多样性的显着变化。接触多氯联苯还导致更高的体脂百分比,更大的腹部皮下脂肪细胞大小以及促炎性细胞因子(包括TNF-α,iNOS和IL-6)的表达增加。共同暴露于H时,此类由PCBs引起的变化可能会进一步增强,这表明肥胖个体可能容易受到PCBs的暴露。综上所述,本研究有助于更好地了解受PCBs和/或H暴露影响的肠道菌群变化,此外,它还提供了关于PCBs-H在宿主肥胖症上相互作用的机制的新颖见解。 (C)2018 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2018年第8期|332-341|共10页
  • 作者单位

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Polychlorinated biphenyls; High-fat diet; Co-exposure; Interaction; Gut microbiota; Obesity;

    机译:多氯联苯;高脂饮食;共同暴露;相互作用;肠道菌群;肥胖;
  • 入库时间 2022-08-17 13:25:53

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