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Maternal arsenic exposure and birth outcomes: A birth cohort study in Wuhan, China

机译:孕产妇砷暴露与出生结局:中国武汉的出生队列研究

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摘要

Maternal arsenic exposure leads to adverse birth outcomes, but the critical window of this susceptibility keeps unclear. To determine whether the associations between maternal arsenic exposure and birth outcomes were trimester-specific, we conducted a birth cohort study of 1390 women from 2014 to 2016 in Wuhan, China. We examined associations between total urinary arsenic concentrations in three trimesters and birth weight, birth length and the risk of small for gestational age (SGA), and the differences of these associations across trimesters using generalized estimating equations. Maternal urinary arsenic concentrations varied across trimesters and were weakly correlated. Arsenic concentrations in the 3rd trimester, but not in the 1st and 2nd trimesters, were associated with birth outcomes. For each doubling of arsenic levels in the 3rd trimester, birth weight was decreased 24.27 g (95% confidence interval (CI): -46.99, -1.55), birth length was decreased 0.13 cm (95% CI: -0.22, -0.04), and the risk for SGA birth was increased 25% (95% CI: 1.03, 1.49). Further, stratified analyses indicated that these associations were only observed in female infants. Our findings indicate maternal arsenic levels in the 3rd trimester seemed to have significant impacts on birth outcomes, and also emphasize the public health interventions relevance to arsenic exposure in late pregnancy. (C) 2018 Elsevier Ltd. All rights reserved.
机译:孕产妇接触砷会导致不良的出生结局,但这种易感性的关键窗口尚不清楚。为了确定孕产妇砷暴露与分娩结局之间的关联是否为孕晚期特异性的,我们在2014年至2016年间在中国武汉市对1390名妇女进行了出生队列研究。我们使用广义估计方程,研究了三个月中总尿砷浓度与出生体重,出生时长和小胎龄风险(SGA)之间的关联,以及三个月之间这些关联的差异。孕期孕妇的尿砷浓度各不相同,且相关性较弱。孕晚期(而不是孕中期和孕中期)的砷浓度与出生结局有关。孕晚期砷水平每增加一倍,出生体重减少24.27 g(95%置信区间(CI):-46.99,-1.55),出生长度减少0.13 cm(95%CI:-0.22,-0.04) ,SGA出生的风险增加了25%(95%CI:1.03,1.49)。此外,分层分析表明这些关联仅在女婴中观察到。我们的研究结果表明,妊娠晚期孕妇的砷水平似乎对出生结局有重大影响,并且还强调了妊娠后期砷暴露与公共卫生干预措施的相关性。 (C)2018 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2018年第5期|817-823|共7页
  • 作者单位

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Dept Obstet & Gynecol, Tongji Med Coll, Union Hosp, Wuhan, Hubei, Peoples R China;

    Wuhan Med & Hlth Ctr Women & Children, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

    Wuhan Polytech Univ, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Dept Chem, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

    Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Critical window; Sex specific; Low-level arsenic; Urine; Cohort;

    机译:临界窗口;性别特异性;低砷;尿液;队列;
  • 入库时间 2022-08-17 13:25:47

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