Increased levels of 8-hydroxy-2'-deoxyguanosine are attributable to organophosphate pesticide exposure among young children

摘要

Oxidative damage has been proposed as an important mechanism linking pesticide exposure to health effects. A study of 268 young Shanghai children was conducted to examine the relationship between organophosphate pesticide (OP) exposure and a biomarker of oxidative DNA damage. Urine samples were analyzed for five nonspecific dialkyl phosphate (DAP) metabolites [dimethyl phosphates (DMs) and diethyl phosphates (DEs)] and 8-hydroxy-2'-deoxyguanosine (8-OHdG). The creatinine-adjusted median of 8-OHdG in urine samples was 3.99 ng/mg. Increased exposure to OPs was associated with greater levels of urinary 8-OHdG [total DAPs: β (adjusted) = 0.46 per log_(10) unit increase, 95% confidence interval (CI) = 0.40-0.53, p = 0.000; DMs: β (adjusted) = 0.34,95% CI = 0.28-0.41, p = 0.000; DEs: β (adjusted) = 0.48, 95% CI = 0.42-0.54, p = 0.000]. Thus, the 8-OHdG biomarker is useful for increasing our understanding of the link between childhood exposure to OPs and health outcomes.