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首页> 外文期刊>Environmental Health and Preventive Medicine >Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat
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Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat

机译:高脂高胆固醇饮食诱导的脂肪性肝炎和严重纤维化的同时变化及其潜在分子机制在新型SHRSP5 / Dmcr大鼠中

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摘要

The aim of this study was to identify the molecular mechanisms underlying high-fat and high-cholesterol (HFC) diet-induced steatohepatitis and associated liver fibrosis progression in a novel stroke-prone, spontaneously hypertensive 5/Dmcr (SHRSP5/Dmcr) rat model.
机译:这项研究的目的是确定一种新型的易发中风,自发性高血压5 / Dmcr(SHRSP5 / Dmcr)大鼠模型中高脂和高胆固醇(HFC)饮食诱导的脂肪性肝炎以及相关肝纤维化进展的分子机制。

著录项

  • 来源
    《Environmental Health and Preventive Medicine》 |2012年第6期|p.444-456|共13页
  • 作者单位

    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan;

    Department of Food and Nutritional Environment, Kinjo Gakuin University, Nagoya, Aichi, Japan;

    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan;

    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan;

    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan;

    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan;

    Department o;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Steatohepatitis; Inflammation; TNF-α; NF-κb; Fibrosis;

    机译:脂肪性肝炎;炎症;TNF-α;NF-κb;纤维化;

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