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Local- and regional-scale air pollution modelling (PM_(10)) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC)

机译:地方和区域规模的空气污染模型(PM_(10))以及妊娠中期,婴儿期和15岁以下儿童的暴露评估:雅芳父母和儿童纵向研究(ALSPAC)

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摘要

We established air pollution modelling to study particle (PM10) exposures during pregnancy and infancy (1990-1993) through childhood and adolescence up to age similar to 15 years (1991-2008) for the Avon Longitudinal Study of Parents And Children (ALSPAC) birth cohort. For pregnancy trimesters and infancy (birth to 6 months; 7 to 12 months) we used local (ADMS-Urban) and regional/long-range (NAME-III) air pollution models, with a model constant for local, non-anthropogenic sources. For longer exposure periods (annually and the average of birth to age similar to 8 and to age similar to 15 years to coincide with relevant follow-up clinics) we assessed spatial contrasts in local sources of PM10 with a yearly-varying concentration for all background sources. We modelled PM10 (mu g/m(3)) for 36,986 address locations over 19 years and then accounted for changes in address in calculating exposures for different periods: trimesters/infancy (n = 11,929); each year of life to age similar to 15 (n = 10,383). Intra-subject exposure contrasts were largest between pregnancy trimesters (5th to 95th centile: 24.4-37.3 mu g/m(3)) and mostly related to temporal variability in regional/long-range PM10. PM10 exposures fell on average by 11.6 mu g/m(3) from first year of life (mean concentration = 31.2 mu g/m(3)) to age similar to 15 (mean = 19.6 mu g/m(3)), and 5.4 mu g/m(3) between follow-up clinics (age similar to 8 to age similar to 15). Spatial contrasts in 8-year average PM10 exposures (5th to 95th centile) were relatively low: 25.4-30.0 mu g/m(3) to age similar to 8 years and 20.7-23.9 mu g/m(3) from age similar to 8 to age similar to 15 years. The contribution of local sources to total PM10 was 18.5%-19.5% during pregnancy and infancy, and 14.4%-17.0% for periods leading up to follow-up clinics. Main roads within the study area contributed on average similar to 3.0% to total PM10 exposures in all periods; 9.5% of address locations were within 50 m of a main road. Exposure estimates will be used in a number of planned epidemiological studies.
机译:我们建立了空气污染模型,以研究雅芳纵向父母研究(ALSPAC)出生的婴儿和孕妇(1990-1993)直至儿童和青春期直至15岁左右(1991-2008)的颗粒(PM10)暴露。队列。对于孕中期和婴儿期(出生至6个月; 7至12个月),我们使用局部(ADMS-城市)和区域/远程(NAME-III)空气污染模型,该模型对于局部非人为来源的模型恒定。对于更长的暴露时间(每年和与相关随访诊所相吻合的平均出生年龄为8岁和15岁左右的平均出生年龄),我们评估了所有背景下PM10本地来源的浓度在逐年变化的空间对比资料来源。我们对19年中36,986个地址的PM10(μg / m(m)/ m(3))进行了建模,然后在计算不同时期的暴露时考虑了地址变化:孕中期/婴儿期(n = 11,929);每一岁至15岁(n = 10,383)。受试者在妊娠中期之间的暴露对比最大(第5至95个百分位数:24.4-37.3μg / m(3)),并且与区域/远程PM10的时间变异性有关。从生命的第一年(平均浓度= 31.2μg / m(3))到接近15岁的年龄(平均= 19.6μg / m(3)),PM10暴露平均下降11.6μg / m(3),随访诊所之间的距离为5.4μg / m(3)(年龄在8岁至15岁之间)。 8年平均PM10暴露量(第5至95个百分位数)的空间对比相对较低:与8岁相似的年龄为25.4-30.0μg / m(3),与8岁相似的年龄为20.7-23.9 mu g / m(3) 8岁到15岁相似。在孕期和婴儿期,当地资源对总PM10的贡献为18.5%-19.5%,而在随访诊所前的这段时间内,这一贡献为14.4%-17.0%。在所有时期,研究区内的主要道路平均占PM10暴露总量的3.0%; 9.5%的地址位置位于主干道50 m以内。暴露估计将用于许多计划的流行病学研究中。

著录项

  • 来源
    《Environment international》 |2018年第4期|10-19|共10页
  • 作者单位

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Univ Bristol Sch Med, Populat Hlth Sci, Bristol, Avon, England;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Imperial Coll London, Dept Epidemiol & Biostat, UK Small Area Hlth Stat Unit SAHSU, London, England;

    Univ Bristol Sch Med, Populat Hlth Sci, Bristol, Avon, England;

    Met Off, Exeter, Devon, England;

    Met Off, Exeter, Devon, England;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;

    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    ALSPAC; Air pollution; Dispersion modelling; Exposure assessment; Mother-child; PM10;

    机译:ALSPAC;空气污染;色散建模;暴露评估;母婴;PM10;
  • 入库时间 2022-08-17 13:23:27

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