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Air pollution and occurrence of type 2 diabetes in a large cohort study

机译:一项大型队列研究中的空气污染和2型糖尿病的发生

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The few cohort studies that have investigated the association between exposure to air pollution and occurrence of diabetes have reported conflicting results. We aimed to evaluate the association of long-term exposure to particulate matter (PM), nitrogen oxides (NOx) and ozone (O-3), with baseline prevalence and incidence of type 2 diabetes in a large administrative cohort in Rome, Italy. A total of 1,425,580 subjects aged 35 + years (January 1st, 2008) were assessed and followed for six years. We estimated PM10, PM2.5-10, PM2.5, NO2, and NOx exposures at residence using land use regression models, and summer O-3 exposure using dispersion modeling. To estimate the association between air pollutant exposures and prevalence and incidence of diabetes, we used logistic and Cox regression models, considering individual, environmental (noise and green areas), and contextual characteristics. We identified 106,387 prevalent cases at baseline and 65,955 incident cases during the follow-up period. We found positive associations between nitrogen oxides exposures and prevalence of diabetes with odds ratios (ORs) up to 1.010 (95% CI: 1.002, 1.017) and 1.015 (1.009, 1.021) for NO2 and NOx, respectively, per fixed increases (per 10 mu g/m(3) and 20 mu g/m(3), respectively). We also found some evidence of an association between NOx and O-3 and incidence of diabetes, with hazard ratios (HRs) of 1.011 (95% CI: 1.003-1.019) and 1.015 (1.002-1.027) per 20 and 10 mu g/m(3) increases, respectively. The association with O-3 with incident diabetes was stronger in women than in men and among those aged 50 years. In sum, long-term exposure to nitrogen oxides was associated with prevalent diabetes while NOx and O-3 exposures were associated with incident diabetes.
机译:少数研究空气污染与糖尿病发生之间关系的队列研究报告了相互矛盾的结果。我们的目的是评估意大利罗马的一个大型行政队列中长期暴露于颗粒物(PM),氮氧化物(NOx)和臭氧(O-3)与2型糖尿病的基线患病率和发病率之间的关系。总共对1,425,580名年龄在35岁以上(2008年1月1日)的受试者进行了评估,并随访了6年。我们使用土地利用回归模型估算了居住地的PM10,PM2.5-10,PM2.5,NO2和NOx暴露量,并使用分散模型估算了夏季O-3暴露量。为了估计空气污染物暴露与糖尿病患病率和发病率之间的关系,我们使用了逻辑和Cox回归模型,并考虑了个体,环境(噪声和绿色区域)和环境特征。我们在基线期间确定了106,387例流行病案例,在随访期间发现了65,955例事件案例。我们发现氮氧化物暴露与糖尿病患病率之间呈正相关,每固定增加(每10个),NO2和NOx的比值比(OR)分别高达1.010(95%CI:1.002,1.017)和1.015(1.009,1.021)。克/平方米(3)和20克/平方米(3))。我们还发现了一些证据表明,NOx和O-3与糖尿病的发病率之间存在相关性,每20和10μg / g的危险比(HRs)为1.011(95%CI:1.003-1.019)和1.015(1.002-1.027) m(3)分别增加。女性与O-3与偶发性糖尿病的关联性强于男性,且年龄在50岁以下者。总而言之,长期暴露于氮氧化物与流行的糖尿病有关,而NOx和O-3暴露与发生糖尿病有关。

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