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Review of antibiotic resistance in China and its environment

机译:中国及其环境对抗生素的耐药性综述

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摘要

Antibiotic resistance is a global health crisis linked to increased, and often unrestricted, antibiotic use in humans and animals. As one of the world's largest producers and consumers of antibiotics, China is witness to some of the most acute symptoms of this crisis. Antibiotics and antibiotic resistance genes (ARGs) are widely distributed in surface water, sewage treatment plant effluent, soils and animal wastes. The emergence and increased prevalence of ARGs in the clinic/hospitals, especially carbapenem-resistant gram negative bacteria, has raised the concern of public health officials. It is important to understand the current state of antibiotic use in China and its relationship to ARG prevalence and diversity in the environment. Here we review these relationships and their relevance to antimicrobial resistance (AMR) trends witnessed in the clinical setting. This review highlights the issues of enrichment and dissemination of ARGs in the environment, and also future needs in mitigating the spread of antibiotic resistance in the environment, particularly under the 'planetary health' perspective, i.e., the systems that sustain or threaten human health.
机译:抗生素耐药性是一种全球性健康危机,与人类和动物对抗生素的使用增加(通常不受限制)有关。作为世界上最大的抗生素生产和消费国之一,中国见证了这场危机最严重的症状。抗生素和抗生素抗性基因(ARG)广泛分布在地表水,污水处理厂废水,土壤和动物粪便中。临床/医院中ARG的出现和流行,特别是对碳青霉烯耐药的革兰氏阴性菌,引起了公共卫生官员的关注。了解中国抗生素的使用现状及其与ARG流行和环境多样性的关系非常重要。在这里,我们回顾了这些关系及其与临床环境中所观察到的抗菌素耐药性(AMR)趋势的相关性。这篇综述着重介绍了环境中ARG的富集和传播问题,以及在减轻抗生素耐药性在环境中的传播方面的未来需求,特别是从``行星健康''的角度来看,即维持或威胁人类健康的系统。

著录项

  • 来源
    《Environment international》 |2018年第1期|160-172|共13页
  • 作者单位

    Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    NERC Ctr Ecol & Hydrol, Wallingford OX10 8BB, Oxon, England;

    Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China|Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Antibiotics; Antibiotic resistance gene; Environment; Clinical setting; Planetary health;

    机译:抗生素;抗生素抗性基因;环境;临床环境;行星健康;
  • 入库时间 2022-08-17 13:23:26

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