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Estrogen and non-feminizing estrogen for Alzheimer's disease.

机译:阿尔茨海默氏病的雌激素和非女性雌激素。

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The preventive effect of estrogen on Alzheimer's disease (AD) has become clearer with many epidemiological reports. However, the therapeutic effects of estrogen have been controversial until now. In our trials, estrogen treatment showed a beneficial therapeutic effect for women with mild to moderate AD. Improvement of cognitive function was recognized during the third week from the beginning of administration and maintained as long as estrogen treatment continued. The longer the duration of HRT, the more HRT is useful for the prevention and therapy of AD. However, in most cases, administration of estrogen is discontinued because of the adverse effects on the uterus and breast. J 861 is a derivative of estradiol-17alpha, which has little effect on the sexual organs. The effects of estradiol-17beta (E2) and J 861 on neuronal function and vascular factors were investigated. J 861 was suggested to prevent both the intracellular calcium increase and peroxidation induced by amyloid beta (Abeta), more effectively than E2. The effect of J 861 may be related with both the direct non-genomic and the ER-mediated systems. J 861 showed neurotrophic effects like E2. J 861 inhibited the adhesion of monocytes to vascular endothelium, more effectively than E2. Also, J 861 suppressed the expression of adhesive factors, such as E-selectin and intercellular cell adhesion molecule-1 (ICAM-1), more effectively than E2.
机译:在许多流行病学报告中,雌激素对阿尔茨海默氏病(AD)的预防作用已变得更加清晰。然而,迄今为止,雌激素的治疗​​作用一直存在争议。在我们的试验中,雌激素治疗对轻至中度AD的妇女显示出有益的治疗效果。从给药开始的第三周就认识到认知功能的改善,并且只要雌激素继续治疗就可以维持。 HRT持续时间越长,HRT对AD的预防和治疗就越有用。然而,在大多数情况下,由于对子宫和乳房的不利影响,停止给予雌激素。 J 861是雌二醇17alpha的衍生物,对性器官的影响很小。研究了雌二醇-17β(E2)和J 861对神经元功能和血管因子的影响。建议使用J 861比E2更有效地防止淀粉样β(Abeta)诱导的细胞内钙增加和过氧化。 J 861的作用可能与直接的非基因组系统和ER介导的系统有关。 J 861表现出类似E2的神经营养作用。 J 861比E2更有效地抑制单核细胞粘附到血管内皮。同样,J 861比E2更有效地抑制了粘附因子的表达,例如E-选择蛋白和细胞间细胞粘附分子1(ICAM-1)。

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