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The Higher Immuno reactivity to ACE (Angiotensin Converting Enzyme) in Patients with Type 2 Diabetes Mellitus than in Non-Diabetic Individuals

机译:2型糖尿病患者对ACE(血管紧张素转换酶)的免疫反应性高于非糖尿病患者

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In a random sample of 200 patients with type 2 diabetes mellitus, immunoreactivities to ACE (angiotensin converting enzyme) were measured by ELISA. Immunoreactivities were positive for 129 (64.5%) patients, and were positive in 30 (83.3%) out of 36 patients in the early stage of clinical diabetic nephropathy. Serum ACE activity in rabbits immunized with ACE decreased to 50% of the control level after 7 months (78.0 +- 3.8 IU/L/37℃, basal, 42.0 +- 5.0 at 7 months and 33.3 +- 3.5 1U/L/37℃ at 8 months, respectively). When rabbit serum containing antiACE antibodies was mixed, after heat-treatment at 56℃ for 30 min, with normal human serum, the ACE activity was reduced in a concentration-dependent manner. These results suggested that anti-ACE autoantibody may be present in patients with type 2 diabetes mellitus. However, the absence of data on the epitope for the antibody does not allow any conclusion except that the immunoreactivities to ACE are higher in type 2 diabetic patients than in non-diabetic individuals.
机译:在200名2型糖尿病患者的随机样本中,通过ELISA测定了对ACE(血管紧张素转化酶)的免疫反应性。在临床糖尿病肾病的早期阶段,免疫反应阳性的患者为129名(64.5%),在36名患者中有30名(83.3%)为阳性。 7个月后,经ACE免疫的兔子的血清ACE活性降至对照水平的50%(78.0±3.8 IU / L / 37℃,基础,7个月为42.0±5.0和33.3±3.5 1U / L / 37 ℃分别在8个月)。当将含有抗ACE抗体的兔血清与正常人血清混合后,在56℃热处理30分钟后,ACE活性以浓度依赖性方式降低。这些结果表明抗ACE自身抗体可能存在于2型糖尿病患者中。但是,抗体表位上的数据缺乏,无法得出任何结论,除了2型糖尿病患者对ACE的免疫反应性高于非糖尿病个体。

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