首页> 外文期刊>Endocrine journal >Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia.
【24h】

Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia.

机译:多囊卵巢综合征和先天性肾上腺增生的血浆同型半胱氨酸水平。

获取原文
获取原文并翻译 | 示例
       

摘要

The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, 50 patients with CAH and 25 control women were included in the study. Blood samplings were performed in the early follicular phase for measuring hormone profile, Vitamin B(12), folate, homocysteine levels and fasting blood glucose. Ovulatory status was assessed with timed serum progesterone measurements. Homeostasis model assessment-insulin resistance (HOMA-IR) was calculated as a measure of insulin resistance. Mean homocysteine levels were found as (8.9 + 1.9 micromol/l and 17.7 + 3.6 micromol/l) in the normal group and PCOS respectively (p<0.001), but there was no statistical significance between nonclassic 21-hydroxylase deficiency (9.0 + 2.2 micromol/l) and control group. Most of the patients in PCOS group (35 of 50) were significantly insulin resistant. However, there was no insulin resistant patient in CAH or control group. When we compare the two subgroups of PCOS women, the patients with insulin resistance had significantly higher homocysteine levels than the ones who were not insulin resistant. There were positive correlations among serum homocysteine, insulin and androgen levels in PCOS patients. There were no correlations among these parameters in CAH and control groups. Increased homocysteine levels may contribute to increased cardiovascular disease risk in patients with PCOS. The reason for hyperhomocysteinemia seems to be related to insulin resistance but not high androgen levels.
机译:这项研究的目的是确定多囊卵巢综合征(PCOS)和非经典21-羟化酶缺乏症(CAH)是否与高同型半胱氨酸血症相关,并研究PCOS和CAH患者的同型半胱氨酸水平与胰岛素敏感性之间是否存在相关性。该研究包括了50名PCOS患者,50名CAH患者和25名对照女性。在卵泡早期进行血液采样以测量激素谱,维生素B(12),叶酸,高半胱氨酸水平和空腹血糖。通过定时血清孕酮测量评估排卵状态。稳态模型评估-胰岛素抵抗(HOMA-IR)被计算为胰岛素抵抗的量度。正常组和PCOS的平均高半胱氨酸水平分别为(8.9 + 1.9微摩尔/升和17.7 + 3.6微摩尔/升)(p <0.001),但非经典21-羟化酶缺乏症(9.0 + 2.2)之间无统计学意义。 micromol / l)和对照组。 PCOS组中的大多数患者(50名患者中的35名)都具有明显的胰岛素抵抗。但是,CAH或对照组中没有胰岛素抵抗患者。当我们比较PCOS妇女的两个亚组时,胰岛素抵抗患者的同型半胱氨酸水平明显高于不胰岛素抵抗的患者。 PCOS患者血清同型半胱氨酸,胰岛素和雄激素水平之间呈正相关。在CAH和对照组中,这些参数之间没有相关性。同型半胱氨酸水平升高可能导致PCOS患者心血管疾病的风险增加。高同型半胱氨酸血症的原因似乎与胰岛素抵抗有关,但与雄激素水平无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号