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No Ghrelin Response To Oral Glucose In Diabetes Mellitus With Gastroparesis

机译:胃轻瘫的糖尿病患者对口服葡萄糖没有Ghrelin反应

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To investigate the role of ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (men/women: 36/19, mean ± SE of age: 55.1 ± 1.7 years) with or without gastroparesis (diagnosed by the ~(13)C-acetate breath test). We also further examined cardiac autonomic neuropathy by assessing 24-hour variation of the R-R interval in randomly selected 32 patients with diabetes (men/women: 23/9, mean±SE of age: 54.2 ± 2.5 years), and evaluated the influence of autonomic neuropathy on ghrelin. The fasting plasma ghrelin level was significantly lower in diabetes mellitus with gastroparesis than in healthy controls (7.9 ± 0.7 fmol/ml versus 16.6 ± 5.3 fmol/ml, p = 0.006). Patients with diabetes with gastroparesis showed no decrease of plasma ghrelin after glucose loading, unlike patients without gastroparesis or healthy controls. Diabetes mellitus with autonomic neuropathy, but not those without it, also showed no decrease of plasma ghrelin after glucose loading. Diabetic gastroparesis may be related to ghrelin-associated neurohormonal abnormalities, but the pathophysiological meaning of this abnormal ghrelin response needs further clarification.
机译:为了研究生长激素促分泌素受体的内源性生长素释放肽在糖尿病性胃轻瘫中的作用,我们在55名糖尿病患者的口服葡萄糖耐量测试期间评估了血浆生长素释放肽的分布(男性/女性:36/19,平均值±SE年龄:55.1±1.7岁)有或没有胃轻瘫(通过〜(13)C-乙酸呼气试验诊断)。我们还通过评估随机选择的32例糖尿病患者(男性/女性:23/9,年龄的平均±SE:54.2±2.5岁)的RR间隔的24小时变化进一步检查了心脏自主神经病变,并评估了ghrelin的自主神经病。患有胃轻瘫的糖尿病患者的空腹血浆生长素释放肽水平显着低于健康对照组(7.9±0.7 fmol / ml与16.6±5.3 fmol / ml,p = 0.006)。与没有胃轻瘫或健康对照的患者不同,患有胃轻瘫的糖尿病患者显示葡萄糖负荷后血浆生长素释放肽没有降低。患有自主神经病变的糖尿病患者,但未伴有自主神经病变的患者,也未显示葡萄糖负荷后血浆生长素释放肽水平降低。糖尿病性胃轻瘫可能与生长激素释放肽相关的神经激素异常有关,但这种异常生长激素释放肽反应的病理生理学意义需要进一步阐明。

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