Auto- and Alloimmune Reactivity to Human Islet Allografts Transplanted Into Type 1 Diabetic Patients

摘要

Allogeneic islet transplantation can restore an insulin- independent state in C-peptide-negative type 1 dia- betic patients. We recently reported three cases of sur- viving islet allografts that were implanted in type 1 diabetic patients under maintenance immune suppres- sion for a previous kidney graft. The present study compares islet graft-specific cellular auto- and allore- activity in peripheral blood from those three recipients and from four patients with failing islet allografts measured over a period of 6 months after portal islet implantation.