Phylogenetic Analysis of Mitochondrial DNA in Type 2 Diabetes: Maternal History and Ancient Population Expansion

摘要

Several studies have suggested a maternal excess in the transmission of type 2 (non-insulin-dependent) dia- betes. However, the majority of these reports rely on patients recalling parental disease status and hence are open to criticism. An alternative approach is to study mitochondrial DNA (mtDNA) lineages. The hypervariable region 1 of the rapidly evolving noncod- ing section of mtDNA is suitable for investigating maternal ancestry and has been used extensively to study the origins of human racial groups. We have sequenced this 347-bp section of mtDNA from leuko- cytes of subjects with type 2 diabetes (n=630 and age- and race-matched nondiabetic control subjects (n= 57).