Autoantibody Appearance and Risk for Development of Childhood Diabetes in Offspring of Parents With Type 1 Diabetes

摘要

The temporal development of autoantibodies was stud- ied in 1,353 offspring of parents with type 1 diabetes. Islet cell antibodies (ICAs) and autoantibodies to Insulin (IAAs), glutamic acid decarboxylase, and IA-2 Were measured at birth, 9 months, 2 years, and 5 years Of age. At birth, no offspring had islet autoimmunity Other than maternally acquired antibodies, which were Shown to influence antibody prevalence up to age 6 Months. Antibodies detected thereafter were likely to Represent a true de novo production, since prevalences Were the same for offspring from mothers and fathers With diabetes, antibodies detected at 9 months were Almost always confirmed in the 2-year sample and were Associated with an increased likelihood of having or Developing other antibodies.