High-Fat Meals Reduce 24-h Circulating Leptin Concentration in Women

摘要

Leptin induces weight loss in rodents via its effects on food intake and energy expenditure. High-fat diets induce weight gain, but the mechanism is not well understood. Previous studies have not found an effect of dietary fat Content on fasting leptin. There is a nocturnal increase of Leptin, however, which is related to insulin responses to Meals. We have reported that adipocyte glucose utilization Is involved in insulin-induced leptin secretion in vitro. Accordingly, high-fat, low-carbohydrate (HF/LC0 meals, Which induce smaller insulin and glucose responses, Would produce lower leptin concentrations than low-fat, High-carbohydrate (LF/HC) meals.