Induction of Obesity and Hyperleptinemia by Central Glucocorticoid Infusion in the Rat

摘要

It has been claimed that factors favoring the develop- ment or maintenance of animal or human obesity may include increases in glucocorticoid production or hyperresonsiveness of the hypothalamic-pituitary- adrenal axis. In normal rats, glucocorticoids have been shown to be necessary for chronic intracerebroven- tricular infusion of neuropeptide Y to produce obesity and related abnormalities. Conversely, glucocorticoids inhibited the body weight-lowering effect of leptin.