An Insulin Sensitizer Improves the Free Radical Defense System Potential and Insulin Sensitivity in High Fructose-Fed Rats

摘要

Recently there has been growing interest in the effects of antioxidants on insulin activity. In the present study, we investigated the effects of metformin on free radical activity and insulin sensitivity in high fructose-fed rats, a diet that leads to insulin resistance. The animals were divided into four groups (n=16 per group; exper- iment duration =6 weeks): the control (c) group received a standard diet; the control metformin (CM) group was fed a control diet and received metformin (200 mg.kg~-1. Day~-1 in water); the fructose control (FT) group was fed a control diet and received metformin 56.8/100 of the total carbohydrates; and the fructose metformin (FM) group received high-fructose diet and metformin (200 mg. Kg~-1. Day~-1 in water).