Glucosamine Infusion in Rats Rapidly Impairs Insulin Stimulation of Phosphoinositide 3-Kinase But Does Not Alter Activation of Akt/Protein Kinase B in Skeletal Muscle

摘要

Glucosamine, a metabolite of glucose via the hex- osamine biosynthetic pathway, potently induces insulin resistance in skeletal muscle by impairing insulin- induced GLUT4 translocation to the plasma membrane. Activation of phosphoinositide (PI) 3-kinase is neces- Sary for insulin-stimulated GLUT4 translocation, and The serine/threonine kinase Akt/protein kinase B (PKB) is a downstream mediator of some actions of PI 3-kinase.